Strange lag behavior - slow down of Acrobat

I am trying to markup some 3 MB large pdf files. When I open the file Acrobat starts to time “lag”. When I try to turn a page I press the button and can count up to 3 until the new page appears.

When I try to insert comments, it slows down even further. Anybody got an Idea what to do about it?

I have Adobe Acrobat DC (15.006.30201) and Windows 10 (64-Bit) installed. My Computer should be strong enough with i5 3.4GHz and 32 GB RAM.